Ejaculation is controlled by a complex process involving sensory and motor pathways between the penis and the brain. The neurotransmitter serotonin plays a central role in these pathways.
Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is FDA approved for treating anxiety and depression. Patients taking SSRI medicines like sertraline found that a “side effect” they experienced was a delay in ejaculation. Sertraline is prescribed off-label for daily use (most effective) or as needed before sex for treatment of PE. Sertaline has been well studied and is commonly prescribed by doctors for this purpose.
Sildenafil, Viagra, Cialis, Levitra
These medicines are prescribed for erectile dysfunction (ED). Often times, men experiencing ED may also experience PE. In men with both conditions, treatment of ED has been shown to be beneificial for PE. When the ED is a treated, it can lead to a reduction in stress and performance anxiety, as well as needing less stimulation to stay erect. This is thought to help delay ejaculation in these cases. We most commonly prescribe Sildenfil (active ingredient in Viagra) to take as needed before sex.